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The Drug Rediscovery Protocol (DRUP Trial)

Last updated: January 25, 2023

This is a prospective, non-randomized clinical trial that aims to describe the efficacy and toxicity of commercially available, targeted anticancer drugs* prescribed for treatment of patients with advanced cancer.


The Drug Rediscovery Protocol



Reference code


Intervention model

Parallel Assignment

Full description

This is a prospective, non-randomized clinical trial that aims to describe the efficacy and toxicity of commercially available, targeted anticancer drugs* prescribed for treatment of patients with advanced cancer with a potentially actionable variant as revealed by a genomic or protein expression test. The study also aims to simplify patient access to approved targeted therapies that are contributed to the program by collaborating pharmaceutical companies and to perform next generation sequencing on tumor biopsies for biomarker analyses. Eligible patients have an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma for which standard treatment options are no longer available and acceptable performance status and organ function. A genomic or protein expression test must have been performed on the tumor and the results must identify at least one potentially actionable molecular variant as defined in the protocol. Results from the molecular profiling test will be used to determine an appropriate drug(s) from among those available in the protocol. The choice of drug will be supported by a list of potential profiles, a molecular tumor board, a knowledge library and by study coordinators for review and approval of the match. The protocol-specified treatment will be administered to the patient once any drug-specific eligibility criteria are confirmed and a fresh pre-treatment biopsy is performed for future genetic studies. All patients who receive treatment with a drug available in the protocol will be followed for standard efficacy outcomes including tumor response, progression-free and overall survival as well as duration of treatment. In addition, treatment related toxicity will be evaluated.

Inclusion criteria

  1. Adult (age >18 years) patient with a histologically-proven locally advanced or metastatic solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma who is no longer benefitting from standard anti-cancer treatment or for whom no such treatment is available or indicated.

    * For GBM patients: Histologically confirmed recurrent or de novo glioblastoma (primary), with unequivocal first progression after radiotherapy and concurrent/adjuvant chemotherapy, at least 3 months after the concomitant part of the chemo-radiotherapy, and with stable or decreasing dosage of steroids for at least 7 days prior to the baseline MRI scan.

  2. ECOG performance status 0-2
  3. Patients must have acceptable organ function as defined below. However, specific inclusion/exclusion criteria specified in the drug-specific study manual will take precedence:
    1. Absolute neutrophil count ≥ 1.5 x 109/l
    2. Hemoglobin > 5.6 mmol/l
    3. Platelets > 75 x 109/l
    4. Total bilirubin < 2 x ULN
    5. AST (SGOT) and ALT (SGPT) < 2.5 x institutional ULN (or < 5 x ULN in patients with known hepatic metastases)
    6. Serum creatinine ≤ 1.5 × ULN or calculated or measured creatinine clearance ≥ 50 mL/min/1.73 m2
  4. Patients must have objectively evaluable or measurable disease (by physical or radiographic examination, according to RECIST v1.1 for patients with solid tumors, or according to IMWG, Lugano, RANO or GCIG criteria, resp., for patients with multiple myeloma, non-Hodgkin lymphoma, glioblastoma or ovarian cancer in case of CA125-based evaluation (please refer to appendices for further details) [16, 17].
  5. Results must be available from a tumor genomic or protein expression test. Eligible tests may include any of the following technologies: fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR), comparative genomic hybridization (CGH), next generation sequencing (NGS) or immunohistochemistry (IHC). The test may have been performed on the primary tumor or a metastatic deposit, in a diagnostic laboratory or within the context of another CPCT study, and must reveal a potentially actionable variant as defined in Section 5. The test results (full pathology or molecular diagnostics report) must be uploaded in the eCRF.
  6. Patients must have a tumor profile for which single agent treatment with one of the EMA approved targeted anti-cancer drugs included in this study has potential clinical benefit based on preclinical data or clinical information (see section 5).
  7. A new (obtained ≤2 months before inclusion, and without any type of anti-cancer therapy within those ≤2 months ) fresh frozen tumor biopsy specimen for extensive biomarker testing is mandatory before the start of treatment with a targeted agent included in the protocol.

    *For GBM patients:

    The mandatory fresh frozen tumor biopsy sample can be obtained through standard-of-care surgical procedures (i.e., performed at progression, for cytoreduction, to proof progressive disease, or to reduce mass effect on the surrounding brain tissue). Thus, surgical procedures are standard-of-care and not part of trial participation. Fresh frozen tumor tissue must have been obtained ≤2 months before inclusion, and without any type of anti-cancer therapy within those ≤2 months. After surgical procedures, patients must meet the following inclusion criteria:

    i. Surgery must have confirmed the recurrence. ii. A post-surgery MRI should be available within 48 hours following surgery, and must show residual and measurable disease.

    iii. Craniotomy or intracranial biopsy site must be adequately healed free of drainage or cellulitis, and the underlying cranioplasty must appear intact at the time of study inclusion.

  8. Ability to understand and the willingness to sign a written informed consent document.
  9. For orally administered drugs, the patient must be able to swallow and tolerate oral medication and must have no known malabsorption syndrome.
  10. Because of the risks of drug treatment to the developing foetus, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of study participation, and for four months following completion of study therapy. Male patients should avoid impregnating a female partner. Male patients, even if surgically sterilized, (i.e. post-vasectomy) must agree to one of the following: practice effective barrier contraception during the entire study treatment period and through 4 months after the last dose of study drug, or completely abstain from sexual intercourse.

Exclusion criteria

  1. Ongoing toxicity > grade 2, other than alopecia.
  2. Patient is receiving any other anti-cancer therapy (cytotoxic, biologic, radiation, or hormonal other than for replacement) except for medications that are prescribed for supportive care but may potentially have an anti-cancer effect (e.g., megestrol acetate, bisphosphonates). These medications must have been started ≥ 1 week prior to enrollment on this study.
  3. Patient is pregnant or nursing.
  4. Patients with known active progressive brain metastases. Patients with previously treated brain metastases are eligible, provided that the patient has not experienced a seizure or had a clinically significant change in neurological status within the 3 months prior to registration. All patients with previously treated brain metastases must be stable for at least 1 month after completion of treatment and off steroid treatment prior to study enrollment.

    * Additional exclusion criteria specific for glioblastoma patients:

    1. Patients who require anti-convulsant therapy must be taking non-enzyme inducing antiepileptic drugs (non-EIAED). EIAED are prohibited. Patients previously on EIAED must be switched to non-EIAED at least 2 weeks prior to randomization.
    2. No radiotherapy within the three months prior to the diagnosis of progression.
    3. No radiotherapy with a dose over 65 Gy, stereotactic radiosurgery or brachytherapy unless the recurrence is histologically proven.
  5. Patients with clinically significant preexisting cardiac conditions, including uncontrolled or symptomatic angina, uncontrolled atrial or ventricular arrhythmias, or symptomatic congestive heart failure are not eligible.
  6. Patients with known left ventricular ejection fraction (LVEF) < 40% are not eligible
  7. Patients with stroke (including TIA) or acute myocardial infarction within 3 months before the first dose of study treatment are not eligible
  8. Patients with any other clinically significant medical condition which, in the opinion of the treating physician, makes it undesirable for the patient to participate in the study or which could jeopardize compliance with study requirements including, but not limited to: ongoing or active infection, significant uncontrolled hypertension, or severe psychiatric illness/social situations.


Meander Medical Center Recruiting
Amersfoort, Utrecht, Netherlands, 3818 ES
Contact: H.J. Bloemendal, MD
Principal Investigator: G.A. Cirkel, MD
Noordwesr ziekenhuis Alkmaar (NWZ) Recruiting
Alkmaar, Netherlands
Contact: M.P. Hendriks, MD, PhD
Principal Investigator: M.P. Hendriks, MD, PhD
Ziekehuisgroep Twente Recruiting
Almelo, Netherlands
Contact: Siemerik
Principal Investigator: Siemerik
Netherlands Cancer Institute Recruiting
Amsterdam, Netherlands, 1066CX
Contact: E.E. Voest, prof.    0031205129111
Contact: L. Zeverijn, MD    0031205129111
VUMC Recruiting
Amsterdam, Netherlands, 1081 HV
Contact: M Labots
Principal Investigator: M Labots
Amsterdam UMC Recruiting
Amsterdam, Netherlands, 1105AZ
Contact: Adriaan Bins, MD, PhD
Principal Investigator: A Bins, MD, PhD
Onze Lieve Vrouwe Gasthuis (OLVG) Recruiting
Amsterdam, Netherlands
Contact: E.D. Kerver
Principal Investigator: E.D. Kerver
Gelre ziekehuizen Recruiting
Apeldoorn, Netherlands
Contact: S.C.S. Tromp
Principal Investigator: S.C.S. Tromp
Rijnstate Recruiting
Arnhem, Netherlands
Contact: van Voorthuizen
Principal Investigator: van Voorthuizen
Amphia Hospital Recruiting
Breda, Netherlands
Contact: H. Westgeest, MD, PhD
Principal Investigator: H. Westgeest, MD, PhD
Reiner de Graaf Gasthuis Recruiting
Delft, Netherlands
Contact: V.O. Dezentje
Principal Investigator: V.O. Dezentje
Haaglanden medisch centrum Recruiting
Den Haag, Netherlands
Contact: Jeurissen
Principal Investigator: Jeurissen
Haga ziekehuis Recruiting
Den Haag, Netherlands
Contact: Hautsma
Principal Investigator: Hautsma
Deventer ziekenhuis Recruiting
Deventer, Netherlands
Contact: Imholz
Principal Investigator: Imholz
Ziekehuis Nij Smellinghe Recruiting
Drachten, Netherlands
Contact: Hovenga
Principal Investigator: Hovenga
Ziekehuis Gelderse Vallei Recruiting
Ede, Netherlands
Contact: de Mol
Principal Investigator: dr Mol
Maxima Medisch Centrum Recruiting
Eindhoven, Netherlands, 5631 BM
Contact: G Vreugdenhil, MD, PhD
Principal Investigator: G Vreugdenhil, MD, PhD
Orbis Concern Recruiting
Geleen, Netherlands, 6162 BG
Contact: F L Erdkamp, MD
Principal Investigator: F L Erdkamp, MD
Rivas zorggroep Recruiting
Gorinchem, Netherlands
Contact: M.A. Davidis
Principal Investigator: M.A. Davidis
Martini Recruiting
Groningen, Netherlands
Contact: van Rooijen
Principal Investigator: van Rooijen
University Medical Center Groningen Recruiting
Groningen, Netherlands
Contact: D.J.A. de Groot, MD, PhD
Principal Investigator: D.J.A. de Groot, MD, PhD
Spaarne gasthuis Recruiting
Haarlem, Netherlands
Contact: G.J. de Klerk
Principal Investigator: G.J. de Klerk
Treant zorggroep Recruiting
Hoogeveen, Netherlands
Contact: Oldenhuis
Principal Investigator: Oldenhuis
Medisch Centrum Leeuwaarden Recruiting
Leeuwarden, Netherlands
Contact: de Graaf
Principal Investigator: de Graaf
Leiden University Medical Center Recruiting
Leiden, Netherlands
Contact: A.J. Gelderblom, MD, PhD
Principal Investigator: A.J. Gelderblom, MD, PhD
Maastricht University Medical Center Recruiting
Maastricht, Netherlands
Contact: A. Hoeben, MD, PhD
Principal Investigator: A. Hoeben, MD, PhD
St. Antonius ziekhuis Recruiting
Nieuwegein, Netherlands
Contact: Los
Principal Investigator: Los
Radboud umc Recruiting
NIjmegen, Netherlands, 6225GA
Contact: C.M.L. van Herpen, MD, PhD
Principal Investigator: H Verheul, MD, PhD
Bravis Recruiting
Roosendaal, Netherlands
Contact: Boudewijn
Principal Investigator: Boudewijn
St. Fransicus Gasthuis Recruiting
Rotterdam, Netherlands, 3045 PM
Contact: A P Hamberg, MD
Principal Investigator: A P Hamberg, MD
Erasmus MC Recruiting
Rotterdam, Netherlands
Contact: M.J.A. de Jonge, MD, PhD
Principal Investigator: M.J.A. de Jonge, MD, PhD
St. Elisabeth Recruiting
Tilburg, Netherlands, 5022 GC
Contact: L.V. Beerepoot, MD, PhD
Principal Investigator: L.V. Beerepoot, MD, PhD
University Medical Center Utrecht Recruiting
Utrecht, Netherlands, 3584CX
Contact: M.H.G. Langenberg, MD, PhD
Principal Investigator: L Devriese, MD, PhD
Viecuri Recruiting
Venray, Netherlands
Contact: van der wouw
Principal Investigator: van der Wouw
Isala Recruiting
Zwolle, Netherlands
Contact: de Groot
Principal Investigator: de Groot


Contact: E.E. Voest, prof. 0031205129111
Contact: D.L. vd Velden, MD 0031205129111