Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas (SCOPES)
Last updated: January 24, 2022
The SCOPES study: Towards reducing the treatment burden for soft tissue sarcoma patients
Dutch title
Kortdurende pre-operatieve radiotherapie bij hoofd- en nek-, romp- en extremiteiten weke delen sarcomen
Acronym
SCOPES
Reference code
NCT04425967
Intervention model
Randomization between the standard arm A of 50 Gy in 5 weeks or arm B with hypofractination of 14x3Gy
Full description
Currently, soft tissue sarcomas (STS) are preoperatively irradiated in a conventionally fractionated regimen of 25 x 2 Gy in five weeks. Recent radiobiological investigations, however, suggest sensitivity to (modest) hypofractionation. Within this study, patients will be randomized to receive either the conventional schedule of 25 x 2 Gy or a shorter preoperative regimen of 14 x 3 Gy, in the hypothesis that both the postoperative wound complication rate until 30 days after surgery, as well as the local control probability at two years are comparable in both arms.
Inclusion criteria
For inclusion criteria, please click here to continue to the IKNL website
Exclusion criteria
For exclusion cirteria, please click here to continue to the IKNL website