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Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas (SCOPES)

Last updated: January 24, 2022

The SCOPES study: Towards reducing the treatment burden for soft tissue sarcoma patients

Dutch title

Kortdurende pre-operatieve radiotherapie bij hoofd- en nek-, romp- en extremiteiten weke delen sarcomen



Reference code


Intervention model

Randomization between the standard arm A of 50 Gy in 5 weeks or arm B with hypofractination of 14x3Gy

Full description

Currently, soft tissue sarcomas (STS) are preoperatively irradiated in a conventionally fractionated regimen of 25 x 2 Gy in five weeks. Recent radiobiological investigations, however, suggest sensitivity to (modest) hypofractionation. Within this study, patients will be randomized to receive either the conventional schedule of 25 x 2 Gy or a shorter preoperative regimen of 14 x 3 Gy, in the hypothesis that both the postoperative wound complication rate until 30 days after surgery, as well as the local control probability at two years are comparable in both arms.

Inclusion criteria

For inclusion criteria, please click here to continue to the IKNL website

Exclusion criteria

For exclusion cirteria, please click here to continue to the IKNL website